Critical Annotated Bibliography Tranexamic Acid Essay

Critical Annotated Bibliography Tranexamic Acid - Essay interpreterAmandip Singh is also a doctor in the department of anaesthesiology at DMCH. The researchers assert that tranexamic blistery significantly decreases melodic phrase loss after operation and reduces the need for blood transfusion among students after undergoing total knee switch (TKR).According to the researchers, Tranexamic acid, which is a synthetic derivative of amino acid lysine, is an effective antifibrinolytic agent. The acid is may reversibly skirt lysine-binding sites on the plasminogen molecules, thus hinder the formation of plasmin. Other researchers have showed increased exercise of tranexamic acid in orthopaedic surgery due to its safety, efficacy and low cost. The research was conducted in a tertiary health care facility after obtaining approval from the hospital heath ethics committee with informal have taken from patients involved in the study. The researchers used randomized double-blinded study i nvolving 40 patients scheduled to undergo one-party TKR for osteoarthritis. Three surgeons who had experience in the field to ensure validity of the test conducted the study. The first half of the universe of discourse was injected with 10mg/kg of tranexamic acid. Conversely, the placebo group underwent the same procedure only that normal saline was used instead of tranexamic acid. ... It was conclude that routine administration of the acid was beneficial to patients undergoing operation. The limitation of the research is that it involved a limited shape of populations. Also, the researchers did not monitor the plasminogen levels, D-dimer, thromboelastography, and fibrin degradation products. In addition, the researchers failed to measure hemoglobin levels of transfused blood and weigh sponges, which could have alter the accuracy of calculations. The text did not have sufficient clinical evidence and literature supporting the use of tranexamic acid in preventing preoperative bl ood loss. The relevance and usefulness of the text to my research is that it informed on the importance of the Tranexamic acid in reducing blood loss during operations in patients. Sekhavat, L., Tabatabaii, A., Dalili, M., Farajkhoda, T., & Tafti, A. (2009). Efficacy of tranexamic acid in reducing blood loss after cesarean section. The Journal Of Maternal-Fetal & Neonatal Medicine. Vol. 22(1), 72-75. The authors of this research journal are medical practitioners at the department of obstetrics and gynecology at Shahod Sehud Hospita, and Health Services, Yard, Iran. They have the cleverness to produce credible research that can be used in any academic research. The careen presented by the researchers is that cesarean section (CS) rate has been on the increase among women delivering and that CS posse many complications as compared to the normal vaginal birth due to complications related to postpartum haemorrhage. The medications that have been used to reduce bleeding include prosta glandins, oxytocin, and methylergonovine. The researchers however feel that tranexamic acid, a synthetic derivative of the amino acid lysine that has been applied for several(prenominal) years in the